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Feasibility analysis and investigation of process for membrane enrichment of volatile oil from Traditional Chinese Medicine of Citrus reticulata Blanco

Authors：

LONG Guanhong1,2, LI Bo1,2, ZHU Huaxu1,2*, GUO Liwei1,2*, PAN Yonglan1,2, CAO Guiping1,2

Units： 1.Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China; 2. Jiangsu Botanical Medicine Refinement Engineering Research Center, Nanjing University of Chinese Medicine, Nanjing 210023, China

KeyWords： membrane activity of screening; volatile oil of Traditional Chinese Medicine; oil-water separation; Citrus reticulata Blanco; process optimization

ClassificationCode：TQ028.8;R284.2;R284.1;R283.6

year,volume(issue):pagination： 2016,36(3):124-130

Abstract：

Objective: To investigate feasibility of membrane enrichment of volatile oil from Traditional Chinese Medicine through membrane enrichment of Citrus reticulata Blanco.Method:The oil-water system of Citrus reticulata Blanco was selected as subject. The effects of parameters (including distribution of pore sizes, character of membrane materials)on the membrane process, especially membrane permeability flux and yield rate of essential oil rate were discussed in order to fix on a appropriate separation conditions. And the membrane material as well as the operating conditions containing pressure, surface rotation speed, temperature were optimized.Further more, we took essential oil of Citrus reticulata Blanco as an example to research on yield and physical and chemical properties change by different treating method as Ethyl acetate extraction and membrane separation, then we compared the amount of limonene of the two kinds of volatile oil extracted separately by Ethyl acetate extraction and membrane separation. Result: it is not much difference on yield rate of essential oil rate of membrane material of polyvinylidene fluoride (PVDF) membrane with MWCO-50 kDa,70 kDa,140 kDa,but the PVDF membrane with MWCO-140 kDa owed higher permeation flux than PVDF membrane with MWCO-50 kDa and 70 kDa. And the optimum conditions of oil-water separation of Citrus reticulata Blanco’s volatile oil were as following:the PVDF membrane with MWCO-140 kDa, temperature at 60 °C, pressure of 0.15 MPa, and the surface rotation speed at 300 r/min. The results also showed that there is no significant difference in the physical and chemical properties of volatile oil extracted by the two methods, but the yield rate of volatile oil of membrane separation is higher than Ethyl acetate extraction, and the amount of limonene of volatile oil of membrane separation is slightly higher than Ethyl acetate extraction.Membrane separation has a great advantage in retaining the integrity of the material, and the enrichment efficiency is slightly higher than the Ethyl acetate extraction, and the entire oil-water separation process does not involve organic solvents, so to overcome the disadvantage of the original Ethyl acetate extraction with organic solvent residue and so on.Conclusion: membrane enrichment process of Traditional Chinese Medicine volatile oil is green, practical and has a good application prospects.in order to push forward the process of widely applying the membrane separation technology into the field of collecting volatile oil.

Funds：

国家自然科学基金项目（81274096，30873449）；国家“十一五”科技支撑计划（2006BAI09B07-03）；江苏省科技厅自然科学基金项目（BK2012855）；江苏省科技厅产学研联合创新资金——前瞻性研究项目（BY2012036）；江苏省六大人才高峰项目（2014-YY-014）；江苏省高校优势学科建设工程资助项目；南京中医药大学校级创新团队资助。

AuthorIntro：

第一作者简介：龙观洪（1989-），女，广西北流人，硕士研究生，从事中药及中药活性成分的研究。E-mail:longguanhong@126.com. *通讯作者，E-mail: huaxu72@126.com,E-mail:guoliwei815@126.com

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