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Membrane permeability for mass transfer of alginate-based microcapsules

Authors： WANG Yunhong1，LIU Xiudong1*，YU Weiting2*，DAI Xiaomin1，MA Xiaojun2

Units： (1. College of Environment and Chemical Engineering, Dalian University, Dalian 116622; 2. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023)

KeyWords： sodium alginate；mircocapsule membrane；mass transfer

ClassificationCode：TQ028.8

year,volume(issue):pagination： 2017,37(2):6-11

Abstract：

Natural polysaccharide alginate shows good biocompatibility, biodegradability, adhesi-
on, as well as unique deformation stress-release characteristics, so that alginate-based microcapsules with outer polyelectrolyte complex membrane are promising carriers for cell culture and sustained/controlled release. Membrane permeability can decide the diffusion and mass transfer properties of alginate-based microcapsules, which is critical for its application in the biomedical field. We mainly discussed the mathematical models of mass transfer on microcapsule membrane, the diffusion behavior of small molecules, macromolecules (such as proteins) and oxygen in alginate-based microcapsules membrane, summarized the influence rules of parameters such as materials properties, pH on membrane permeability. It is hopeful to provide reference for the preparation and application of alginate-based microcapsules.

Funds：

国家自然科学基金项目（21276033），辽宁省“十百千高端人才引进工程”启动基金（辽人社[2012]207号），辽宁省高等学校优秀科技人才支持计划(LR2013057)

AuthorIntro：

第一作者简介：王云红（1990-），女，山西人，硕士生，主要从事高分子材料的研究。* 通讯作者，E-mail:

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