膜科学与技术

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Application performance of aramid-based organic solvent nanofiltration membrane for separation and purification of macrolides molecule

Authors： Sun-Jie Xu, Qian Shen, Li-Han Luo, Zhen-Liang Xu, Jia-Yao Yu, Lan Cao, Yue-Han Cui, Hui Li

Units： State Key Laboratory of Chemical Engineering, Membrane Science and Engineering R&D Lab, Chemical Engineering Research Center, School of Chemical Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, Chin

KeyWords： Organic solvent nanofiltration; aramid; macrolide antibiotics; separation and purification

ClassificationCode：TQ028．8

year,volume(issue):pagination： 2021,41(3):111-117

Abstract：

On the basis of the present problems in the separation and purification process of macrolides, three typical macrolide antibiotics (erythromycin, azithromycin and clarithromycin) were used as examples in this paper. Active polyamide separation layers with different structures and properties were constructed by adopting interfacial polymerization and three modification methods. The surface morphology, chemical composition, pore size and wettability of aramid-based organic solvent nanofiltration (OSN) membrane samples were investigated. The separation performance of macrolides in the purification processes were evaluated. And the influence of modification methods on the purification process were discussed. The experimental results showed that the rejection of azithromycin, erythromycin and clarithromycin in four solvents were 99.9±0.0% (azithromycin/ethanol), 95.4±2.8%(erythromycin/methanol), 97.0±1.4% (erythromycin/butyl acetate) and 99.8±0.0% (clarithromycin/acetone), respectively. Therefore, aramid-based OSN membranes have the good potential application in the separation and purification process of macrolides.

Funds：

国家自然科学基金项目（22078092，21978081和21808060）和教育部高校基本业务费项目（JKA012011001和JKA012011017）

AuthorIntro：

徐孙杰（1990-），男，上海人，博士后，工学博士，主要从事OSN膜研发及溶剂体系分离过程研究

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