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Application of membrane technology in the secondary development of Kangfuyan capsule

Authors： LIU Hongbo 1,2, XU Sining 1,2, TANG Zhishu 2, ZHU Huaxu 3, SONG Zhongxing 1,2, CUI Chunli 1,2, WANG Yujiao1,2, WANG Minggeng 4, CHEN Yanbin 5

Units： 1. Shaanxi University of Chinese Medicine/Co-construction Collaborative Innovation Center for Chinese Medicine Resources Industrialization by Shaanxi & Education Ministry, Xian yang 712083, China; 2. State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources(Cultivation) / Shaanxi Innovative Drug Research Center, Xian yang 712083, China; 3. Jiangsu Provincial Engineering Research Center for Deep Processing of Plant Medicines/Nanjing University of Traditional Chinese Medicine/Jiangsu Province Collaborative Innovation Center for the Industrialization Process of Traditional Chinese Medicine Resources, Nanjing 210023, China；4. Shandong Buchang Pharmaceutical Co., Ltd., Heze, Shandong 274000，China; 5. Shaanxi Buchang Pharmaceutical Co., Ltd., Xi’an 710075, China

KeyWords： Kangfuyan capsule; traditional Chinese medicine; microfiltration; ultrafiltration; alcohol precipitation process; purification

ClassificationCode：TQ028.8

year,volume(issue):pagination： 2021,41(4):117-123

Abstract：

The microfiltration and ultrafiltration membrane technology were applied to the purification of Kangfuyan capsule to study the feasibility of replacing the traditional alcohol precipitation process in secondary development. Taking the physicochemical properties of water extract and dry extract of Kangfuyan capsule as indexes, the purification effects of membrane technology and alcohol precipitation process were analyzed and compared, and the effects of operation conditions on permeate flux and membrane fouling were also investigated. The results showed that the turbidity and viscosity of the water extract of Kangfuyan capsule decreased to some extent after the purification by membrane technology. In the aspect of overall removal of impurities, the alcohol precipitation process is better than the membrane technology, while in the aspect of effective ingredient retention, the membrane technology is better than the alcohol precipitation process. At the same time, membrane technology can reduce the hygroscopicity of dry paste powder of Kangfuyan capsule and improve the stability of dry paste powder. The process parameters, such as pressure and cross flow velocity, have an important influence on permeation flux and membrane fouling. It is necessary to optimize the process to determine the appropriate parameters. According to the research results, it is feasible for the application of membrane technology in the purification of Kangfuyan capsule in the secondary development.

Funds：

国家自然科学基金项目（81803744，81773919, 81873015）；陕西省中药基础与新药研究重点实验室开放基金项目（2017KF01）; 陕西省教育厅重点实验室项目（19JS018）

AuthorIntro：

刘红波（1987-），男，河南周口，讲师，硕士研究生，主要从事中药制剂新技术研究；徐思宁（1992-），女，陕西铜川，硕士研究生，主要从事中药制剂新技术研究

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