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Preparation of cyclodextrin modified membrane and
its application in bilirubin adsorption

Authors： WANG Zhongyan, LI Leilei, KONG Pengfei, LIANG Feixue, JU Jia, FENG Ruijiang, WU Yuanxin, ZHAO Wei, XU Xiaohu

Units： 1College of Petrochemical Engineering, Liaoning Petrochemical University, Fushun 113001, Liaoning, China; 2Department of Gastroenterology, The First People's Hospital of Fuyang Hangzhou, Hangzhou 311499, Zhejiang, China; 3College of Innovation and Entrepreneurship, Liaoning Petrochemical University, Fushun 113001, Liaoning, China

KeyWords： cyclodextrin; membrane; modification; bilirubin; adsorption; oxidation

ClassificationCode：TQ028.8

year,volume(issue):pagination： 2022,42(2):64-71

Abstract：

Oxidized cyclodextrin was prepared by periodate oxidation reaction, and then immobilized on cellulose acetate/polyvinimide blend affinity membrane (CA/PEI membrane) by Schiff base reaction to prepare a cyclodextrin modified CA/PEI membrane (CA/PEI-CD membrane) for bilirubin removal. The changes in membrane surface element composition, membrane structure and membrane tensile strength before and after modification were investigated by XPS, SEM and mechanical properties. The application of CA/PEI-CD membrane in bilirubin adsorption was studied. The effects of initial bilirubin concentration and albumin content in serum on the adsorption capacity of the modified membrane were investigated. The results showed that cyclodextrin (CD) was successfully immobilized. With the increase of the initial concentration of bilirubin, the adsorption capacity of CA/PEI-CD membrane increased. When the initial concentration of bilirubin was 0.35 mmol/L, the maximum adsorption capacity could reach 80.4 μmol (g membrane)-1. However, in real serum, due to the interference of albumin and other components, the adsorption capacity of bilirubin decreased.

Funds：

国家自然科学基金青年基金（21606120）。

AuthorIntro：

王忠岩（1998—），男，山东省安丘人，硕士研究生，研究方向为膜分离

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