膜科学与技术

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Application prospect of enzymatic membrane reactors and chiral separation membranes in functional
sugars production

Authors： HONG Lan, JIANG Shangkun, LIU Meiling, ZHU Yueming, SHI Ting, WANG Yong, SUN Shipeng

Units： State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing, China 211816, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences,Tianjing,China 300308

KeyWords： Functional rare sugars; enzyme membrane reactors; chiral separation; immobilized enzymes

ClassificationCode：TQ050.4

year,volume(issue):pagination： 2022,42(2):146-153

Abstract：

Functional sugars, especially functional rare sugars, are sugars with low calories and special physiological properties. They are mainly produced by enzymatic reactions to date. However, its further development is limited by unfavorable factors such as poor stability, low catalytic efficiency and difficulty in separation of enantiomers from raw materials. Therefore, more attention should be paid to solve the above problems and promote its large-scale preparation. The enzymatic membrane reactors are prepared by coupling enzyme-catalyzed reaction with membrane separation process. The molecular weight distribution of oligosaccharides is controlled and the products are removed in time during the reaction process, which effectively alleviates the inhibition reaction. Nevertheless, the reported enzymatic membrane reactors are mainly used for the separation of enzymes and sugars. The sugars which are enantiomers need to be further isolated and purified by chromatography, resulting in increased cost. Therefore, for the production of functional sugars, this review describes the enzymatic membrane reactors and chiral separation technology in detail. The article will also discuss the prospects of multifunctional membranes in the production and purification of functional rare sugars.

Funds：

天津合成生物技术创新能力提升项目（TSBICIP-KJGG-003-20）

AuthorIntro：

洪兰（1999-），女，贵州安顺人，硕士研究生，研究方向为有机纳滤膜的制备及应用

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