膜科学与技术

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Construction and properties research of anticoagulated asymmetric PMP membrane based on CO2 facilitated transport

Authors： TIAN Yi, ZHU Yixue, TONG Xiao, WANG Minjie, JIA Guiling, CHEN Dajing, HUANG Xiaojun

Units： 1. Zhejiang University, Department of Polymer Science and Engineering, Hangzhou 310027, China; 2. Hangzhou Normal University, School of Pharmacy, Faculty of Medicine, Hangzhou 311121, China; 3. Challenge IM (Beijing) Technology Co., Ltd, Beijing 102600, China

KeyWords： PMP(poly-4-methyl-1-pentene); Layer by layer self-assembly; Asymmetric anticoagulated structure; CO2 gas transport

ClassificationCode：R318.08;TB324；TQ028

year,volume(issue):pagination： 2024,44(3):38-48

Abstract：

In the COVID-19 epidemic era, ECMO(Extracorporeal Membrane Oxygenation), which provides temporary support for the cardiopulmonary function of critically ill patients, is particularly important for humans. However, the core component of ECMO, oxygenated membrane material, has been monopolized by 3M company. Therefore, it is of great significance to realize the localization of oxygenated membrane. PMP(poly-4-methyl-1-pentene) has great potential in oxygenated membrane materials due to its excellent gas permeability and biocompatibility. Here we used PMP hollow fiber membrane prepared by TIPs(Thermally Induced Phase separation) as the substrate, and then introduced the positive and negative charge modification layers composed of PEI (polyethyleneimine) and heparin on the surface through layer by layer self-assembly driven by electrostatic force. Through this work, the PMP composite membrane with asymmetric structure was prepared, and the effects of modification conditions on the surface structure and composition, gas transport, blood compatibility and other properties of the composite membrane were studied. The result showed that the PEI-heparin modification layer introduced by layer-by-layer self-assembly greatly improved the gas transport performance and blood compatibility of the PMP hollow fiber composite membrane, which gave it important application potential in the fields of gas separation and membrane oxygenation.

Funds：

国家自然科学基金资助项目（22075242，52103271），国家自然科学基金区域创新重点项目（U21A20300）

AuthorIntro：

田懿（2002-），女，湖北恩施人，博士生，研究方向为微藻CO2捕集

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