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Research on PVC/PVDF-CTFE blend hollow fiber membranes for blood oxygenation

Authors： RONG Xinyu1， LYU Xiaolong1，2， LIU Juanjuan3， GU Jie1，REN Kai1

Units： 1. State Key Laboratory of Separation Membranes and Membrane Processes,School of Materials Science and Engineering, Institute of Biological and Chemical Engineering, Tiangong University, Tianjin 300387, China; 2. Tianjin Membrane Technology Co.,Ltd. State Key Laboratory of Menbrane Materials and Membrane Applications, Tianjin 300334, China； 3.Tianjin Third Central Hospital Institute of Hepatobiliary Disease, Tianjin 300170, China

KeyWords： artificial lung; polyvinyl chloride; hollow fiber membrane; nonsolvent-induced phase separation method；blood compatibility

ClassificationCode：TQ028.8

year,volume(issue):pagination： 2024,44(6):55-63

Abstract：

Oxygenation membrane is the core material for extracorporeal membrane oxygenation, and there are still many issues regarding the balance of gas exchange efficiency, plasma leakage resistance, and blood compatibility. Polyvinyl chloride (PVC) is a commonly used medical material. In this paper, polyvinyl chloride (PVC) and polyvinylidene fluoride-trifluorovinyl chloride (PVDF-CTFE) materials were first used to prepare oxygenated membranes. The hydrophobic hollow fiber membrane was prepared by non-solvent induced phase separation, and then carboxymethyl cellulose was fixed on the inner surface of hollow fiber membrane by glutaraldehyde crosslinking, and the oxygenated membrane coating with small pore size was constructed. On the one hand, the coating plays a pre-filtration role, prolonging the plasma leakage time, and on the other hand, improving the blood compatibility of the membrane surface. After coating construction, the pore size decreased from 375 nm to 206 nm, and the gas permeation flux was 661±58 mL/(cm2·min·MPa), higher than that of poly(4-methyl-1-pentene) membrane and similar to commercial polypropylene (PP) membrane. The carboxymethyl cellulose coating improved the blood compatibility of the membrane surface, with a BSA adsorption rate of only 0.9%. Compared with commercial PP membrane, the amount of red blood cell adhesion decreased by 46.7%, and the amount of platelet adhesion decreased by 21.4%. The hemolysis rate was only 0.25%, indicating it as a safe biomembrane material. The leakage time of carboxymethyl cellulose coating membrane was extended to 22 hours, which is 3.6 times longer than that of commercial PP membrane. The PVC/PVDF-CTFE oxygenated membrane prepared in this study provides certain guiding significance for the development and design of new membrane materials.

Funds：

天津市科技计划重点项目(15ZCZDGX00280)；天津市高等学校新型膜材料及膜分离技术创新团队(TD13-5044)

AuthorIntro：

荣新雨（1999-），女，山东德州人，硕士研究生，从事膜材料在生物医学领域的应用研究

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