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Research on surface modification of poly-4-methyl-1-pentene hollow fiber oxygenation membranes

Authors： TONG Tong1, ZHAO Wenjing2, LIU Chunling3, YU Zhuangzhuang1,ZHA Shangwen2, ZHANG Shenxiang1

Units： 1. College of Chemistry, Chemical Engineering and Materials Science, Soochow University,Suzhou 215123, China; 2. Shanghai Eco Polymer Sci & Tech Co. , Ltd., Shanghai 201306, China;3. Jiangsu Sujing Group Co., Ltd., Suzhou 215123, China

KeyWords： PMP hollow fiber oxygenation membrane; phosphorylcholine polymer; surface modification; blood compatibility

ClassificationCode：TQ316.6

year,volume(issue):pagination： 2026,46(1):27-36

Abstract：

Poly-4-methyl-1-pentene (PMP) hollow fiber membrane, as the third generation oxygenation membrane, has the advantages of preventing plasma leakage and high gas permeability. However, the poor blood compatibility has become a key issue that restricts long-term use in ECMO. In order to improve its blood compatibility, phosphorylcholine polymer, poly(MPC-co-LMA-co-TSMA) (PMLT) were synthesized. In order to enhance the stability of grafting, the hydroxyl groups were introduced on the surface of PMP membrane by oxidative self-polymerization of gallic acid, and the PMLT was grafted through the chemical bond to form a stable and continuous antithrombotic coating. The results of SEM, FTIR, XPS and water contact angles verified that the GA@PMLT coating was successfully prepared, and the coating could exist stably in normal saline for one week. The GA@PMLT coating did not significantly affect the gas permeability of the membrane, and improved the blood compatibility of the PMP membrane. This study provides a new idea for the blood compatibility modification of oxygenation membrane.

Funds：

姑苏创新创业领军人才计划项目（ZXL2023198）；工业和信息化部生物医用材料创新任务揭榜挂帅项目；江苏省科技厅省重点研发计划，增材制造高性能分离膜关键技术研发（BE2022056)

AuthorIntro：

童童（2001-），男，江西上饶人，硕士研究生，主要研究方向为功能高分子材料

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