膜科学与技术

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Research progress on anticoagulant modification of hemodialysis membranes

Authors： XIE Songchen， XI Zhenyu，CHEN Jiatong， LI Shaohua， ZHANG Xinmiao

Units： Sinopec (Beijing) Research Insititute of Chemical Industry Co.， Ltd.， Beijing 100013， China

KeyWords： hemodialysis membrane; anticoagulant modification; bulk modification; surface functionalization; hemocompatibility

ClassificationCode：R318.08; TQ051.893

year,volume(issue):pagination： 2026,46(1):219-229

Abstract：

Hemodialysis membranes serve as essential carriers in end-stage renal disease (ESRD) treatment and various blood purification modalities, and their anticoagulant performance directly determine dialysis efficiency and clinical safety. Currently commercial membranes are predominantly prepared from hydrophobic polymers such as polyethersulfone (PES), polysulfone (PSf), and polyvinylidene fluoride (PVDF). Although these materials possess excellent mechanical and chemical stability, they readily induce protein adsorption and platelet adhesion, subsequently triggering coagulation cascades and compromising long-term dialysis performance. To reduce dependence on systemic heparin administration and improve hemocompatibility, recent research has focused on surface and bulk anticoagulant modification of dialysis membranes. This review summarizes major surface-engineering strategies, including surface activation, coating construction, layer-by-layer self-assembly, and heparin-mimetic modifications, as well as bulk modification approaches such as sulfonation/carboxylation, covalent grafting of active anticoagulant molecules, functional polymer blending, and anticoagulation-antioxidation synergistic design. Particular attention is given to the associated mechanisms, structural stability and manufacturing feasibility, followed by a comparative evaluation of the strengths and limitations of each strategy. Current evidence suggests that multi-mechanism synergistic modification may overcome the performance bottlenecks of single-mode modification and provides a promising pathway for developing low-heparin or heparin-free dialysis membranes. This work aims to offer theoretical guidance for the design and industrial translation of high-performance hemodialysis membranes.

Funds：

中国石化科技开发项目（225061)

AuthorIntro：

谢松辰（1996-），男，北京人，工程师，研究方向为超微滤膜的制备及改性

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