聚偏氟乙烯中空纤维医用膜的研制初探 |
作者:刘娟娟,吕晓龙,张庆磊,武春瑞,刘嘉铭 |
单位: 中空纤维膜材料与膜过程国家重点实验室,生物化工研究所, |
关键词: PVDF;血液透析膜;膜性能;非溶剂相转化法 |
DOI号: |
分类号: TQ028.8, R318.08 |
出版年,卷(期):页码: 2013,33(4):23-27 |
摘要: |
本文利用非溶剂相转化法,制备不同聚偏氟乙烯(PVDF)改性膜。研究了PVDF与聚乙二醇(PEG)- 400固含量对膜性能的影响,并将PVDF改性膜与市售血液透析膜F60S的性能进行了对比分析。结果表明,随着PVDF固含量的增加,膜分离孔径和纯水通量逐渐减小,BSA截留率和机械性能提高;随着PEG-400固含量的增加,膜分离孔径先减小后增大,BSA截留率先增加后减小,纯水通量逐渐提高,机械性能下降。PVDF/PEG膜分离孔径与纯水通量比F60S膜略低,BSA截留率、机械性能、血液相容性与F60S膜相比均具优势。 |
In this present study, different PVDF modified membranes were prepared by non-solvent induced phase separation (NIPS) method. The effects of PVDF solid content, polyethylene glycol (PEG) - 400 solid content on membranes performances were researched. In addition, the performance of different PVDF modified membranes and F60S membranes, saled on the market, were compared and analysed. The results showed that, the membranes aperture and pure water flux decreases gradually with the increase of PVDF solid content, BSA retention rate and mechanical property increased. The aperture of membranes decreased and then increased with PEG-400 solid content increased, BSA retention rate increased and then decreased gradually, the pure water flux increased, and mechanical properties decreased. The aperture and pure water flux of PVDF/PEG membrane were slightly smaller than F60S membrane, BSA retention rate, mechanical properties and blood compatibility of PVDF/PEG membrane were better than F60S membrane. |
基金项目: |
国家自然科学基金项目(21176188,21106100);高等学校博士学科点专项科研基金(20111201110004);天津市应用基础及前沿技术研究计划项目(11JCYBJC04700,12JCQNJC05500) |
作者简介: |
刘娟娟 (1986?),女,河北省沧州市人,硕士研究生,从事膜材料在生物医学领域的应用,E-mail:athena196121@163.com; |
参考文献: |
[1] 王许云,张林,王新,等.铸膜液溶解温度对制备PVDF微孔膜结构的影响[J].高分子材料科学与工程,2009,25(10):87-90. [2] 李亚静,田鵾鹏,吕晓龙.血液分离用聚偏氟乙烯中空纤维膜的制备[J].膜科学与技术,2011,31(1):36-40. [3] 时钧,袁权,高从堦.膜技术手册[M].北京:化学工业出版社,2001:32-33. [4] 田鵾鹏,向慧玲,李亚静,等.改性聚偏氟乙烯膜的生物相容性研究[J].生物医学工程与临床,2010,14(3):207-211. [5] 逯志平,吕晓龙,武春瑞,等.低温热致相分离法制备聚偏氟乙烯中空纤维多孔膜的研究[J].膜科学与技术,2012,32(1):12-17. [6] Rodrigues MT, Gomes ME, Mano JF, et al. b-PVDF membranes induce cellular proliferation and differentiation in static and dynamic conditions [J]. Mater Sci Forum, 2008, 587(28):72-76. [7] Junge K, Rosch R, Klinge U, et al. Gentamicin supplementation of polyvinylidenefluoride mesh materials for infection prophylaxis [J]. Biomaterials, 2005, 26(35):787-793. [8] Hung CH, Lin YL, Young TH. The effect of chitosan and PVDF substrates on the behavior of embryonic rat cerebral cortical stem cells [J]. Biomaterials, 2006, 27(25):4461-4469. [9] Chan R, Chen V. Characterization of protein fouling on membranes: opportunities and challenges [J]. J Membr Sci, 2004, 242(1-2):169-188. [10] 刘捷,武春瑞,吕晓龙,等.异形聚偏氟乙烯中空纤维膜的研制[J].膜科学与技术,2012,32(1):33-39. [11] 吕晓龙.中空纤维多孔膜性能评价方法探讨[J].膜科学与技术,2011,31(2):1-6. [12] 张炜频,李娜,张钧超,等. 聚乙二醇对聚偏氟乙烯/亲水性高聚物性能影响[J].南昌航空大学学报,2010,24(1):25-29. |
服务与反馈: |
【文章下载】【加入收藏】 |
《膜科学与技术》编辑部 地址:北京市朝阳区北三环东路19号蓝星大厦 邮政编码:100029 电话:010-64426130/64433466 传真:010-80485372邮箱:mkxyjs@163.com
京公网安备11011302000819号