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聚砜膜的低温等离子体改性及其在膜式氧合器的应用

作者：殷海燕¹，刘耀东¹，黄鑫¹，吕权¹，虞文魁²，李磊¹0

单位： 1、南京大学化学化工学院, 江苏南京 210093，2、南京大学医学院，江苏南京 210093

关键词：聚砜膜式氧合器；低温等离子体；接触角；牛血清蛋白吸附

DOI号：

分类号： TB324

出版年,卷(期):页码： 2014,34(4):50-55

摘要：

采用低温等离子体技术对用于膜式氧合器的聚砜（PSF）膜进行表面改性，通过接枝聚乙二醇（PEG）和肝素以改善其血液相容性。系统研究了接枝的PEG分子量及不同等离子体处理条件对改性效果的影响。研究结果表明，当PEG分子量为6000，等离子预处理功率为150W，预处理时间为2min，处理气体为氩气（Ar）时，改性效果最佳，接触角明显降低，蛋白吸附显著减少。膜的汽液双侧传输性质测试结果表明，改性后的PSF膜保留了初始膜的气体传输性能，基本达到了医用人工肺材料的标准。

In this study, polysulfone(PSF) asymmetric membranes used for membrane oxygenator were modified by low temperature plasma technology(LTPT) to improve their hemocompatibility. PSF membrane surface was activated by LTPT, and then polyethylene glycol (PEG) and heparin were grafted onto membrane surface. The effects of PEG molecular weight and plasma treatment conditions on modification results were investigated thoroughly. It was demonstrated through experiments of membranes preparation that the modified membranes had the optimal results such as smaller contact angles and less adsorption of bovine serum albumin when the molecular weight of polyethylene glycol is 6000, the plasma power is 150 watts, the treatment time is 2 minutes and the process gas is argon(Ar). Besides, experimental results of gas-liquid transfer indicated that the modified membranes retained almost the same gas transmission performance as unmodified ones, which proved to reach the standard of medical membrane oxygeantor mainly

基金项目：

江苏省自然科学基金面上项目（BK2012727）

作者简介：

殷海燕（1989—），男，江苏省南通市人，硕士研究生，研究方向为人工肺用膜材料

参考文献：

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