膜科学与技术

冷冻辅助-界面反应法制备ZIF-8衍生物纳滤膜及其药物脱盐性能研究

作者：王程程，孙皓，王乃鑫，纪树兰，安全福

单位：北京工业大学环境与生命学部，北京 100124

关键词：冷冻辅助；原位生长；纳滤膜；ZIF-8；药物脱盐

出版年,卷(期):页码： 2024,44(3):1-9

摘要：

纳滤膜分离技术在药物脱盐领域具有较大应用潜力，而开发高性能的纳滤膜材料仍具有较大挑战。本研究采用冷冻辅助-界面反应法在氧化铝多孔支撑体内部原位生长了ZIF-8分离层，然后通过硫化处理形成ZIF-8衍生物（ZnS），提高了纳滤膜的渗透性和稳定性。通过SEM、EDS、XRD以及FT-IR等手段对ZIF-8及其衍生物复合膜的结构和化学性质进行了表征。将ZIF-8及其衍生物复合膜用于药物脱盐，考察了前驱体摩尔比、浓度以及反应温度对纳滤性能的影响。在最优条件下，ZnS纳滤膜对四环素的截留率为99.1%，对NaCl截留率小于10%，通量为335.6 LMH/MPa，表现出良好的抗生素脱盐性能和稳定性。

The nanofiltration membrane separation technology has great potential for application in the field of pharmaceutical desalination. The development of new membrane materials with high performance has a great challenge. In this study, a ZIF-8 separation layer was prepared on alumina substrate using a freezing assisted-interface reaction method. Subsequently, the ZIF-8 derivatives (ZnS) were formed through sulfurization treatment to improve the permeability and stability of the nanofiltration membrane. The structure and morphology of ZIF-8 and its derivative composite membranes were characterized by SEM, EDS, XRD, FT-IR, and AFM. The obtained ZIF-8 and its derivative composite membranes were used for pharmaceutical desalination. The effects of precursor molar ratio, concentration, and reaction temperature on nanofiltration performance were investigated. With the optimal conditions, the ZnS nanofiltration membrane exhibited a rejection rate of 99.1% for tetracycline, less than 10% for NaCl, and a flux of 335.6 LMH/MPa, demonstrating good pharmaceutical desalination performance and stability.

王程程（1998-），女，山东泰安人，硕士研究生，主要从事金属有机框架纳滤膜的研究

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