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基于CO2促进传输的抗凝血非对称PMP膜的构建及其性能研究

作者：田懿，朱怡学，童霄，王敏洁，贾桂玲，陈大竞，黄小军

单位： 1. 浙江大学高分子科学与工程学系，杭州 310027；2. 杭州师范大学医学部药学院, 杭州311121；3. 成器智造（北京）科技有限公司, 北京102600

关键词：聚-4-甲基-1-戊烯（PMP）；层层自组装；抗凝血非对称；CO2气体传输

DOI号：

分类号： R318.08;TB324；TQ028

出版年,卷(期):页码： 2024,44(3):38-48

摘要：

新冠疫情期间，为重症患者的心肺功能提供短暂支持的ECMO仪器对人类尤为重要，但其核心组件氧合膜材料被3M公司全球垄断。PMP（聚-4-甲基-1-戊烯）由于具有较为优异的气体渗透能力和生物相容性，在氧合器膜材料中有着巨大的潜力。本文通过TIPs法制备PMP中空纤维膜，并以此作为基材通过静电作用力驱动的层层自组装在表面引入PEI和肝素组成的正负电荷改性层，制备了具有非对称结构的PMP复合膜并研究了改性条件对复合膜表面结构组成和气体传输、血液相容性等性能的影响。结果表明，通过层层自组装引入的PEI-肝素改性层极大地提高了PMP中空纤维复合膜的气体传输性能和血液相容性，使其在气体分离、膜式氧合等领域具有了重要的应用潜力。

In the COVID-19 epidemic era, ECMO(Extracorporeal Membrane Oxygenation), which provides temporary support for the cardiopulmonary function of critically ill patients, is particularly important for humans. However, the core component of ECMO, oxygenated membrane material, has been monopolized by 3M company. Therefore, it is of great significance to realize the localization of oxygenated membrane. PMP(poly-4-methyl-1-pentene) has great potential in oxygenated membrane materials due to its excellent gas permeability and biocompatibility. Here we used PMP hollow fiber membrane prepared by TIPs(Thermally Induced Phase separation) as the substrate, and then introduced the positive and negative charge modification layers composed of PEI (polyethyleneimine) and heparin on the surface through layer by layer self-assembly driven by electrostatic force. Through this work, the PMP composite membrane with asymmetric structure was prepared, and the effects of modification conditions on the surface structure and composition, gas transport, blood compatibility and other properties of the composite membrane were studied. The result showed that the PEI-heparin modification layer introduced by layer-by-layer self-assembly greatly improved the gas transport performance and blood compatibility of the PMP hollow fiber composite membrane, which gave it important application potential in the fields of gas separation and membrane oxygenation.

基金项目：

国家自然科学基金资助项目（22075242，52103271），国家自然科学基金区域创新重点项目（U21A20300）

作者简介：

田懿（2002-），女，湖北恩施人，博士生，研究方向为微藻CO2捕集

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