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亲水性大孔径聚氯乙烯中空纤维蛋白分离膜的研制

作者：龙婷婷，吕晓龙

单位： 1省部共建分离膜与膜过程国家重点实验室，材料科学与工程学院，生物化工研究所，天津工业大学，天津300387；2膜材料与膜应用国家重点实验室，天津膜天膜科技股份有限公司，天津300457

关键词：聚氯乙烯；亲水改性；非溶剂致相分离法；蛋白质分离

DOI号：

分类号： TQ028.8

出版年,卷(期):页码： 2024,44(3):97-105

摘要：

以聚氯乙烯（PVC）为膜材料，在成膜混合物中加入亲水性氨基化合物葡甲胺，葡甲胺的氨基-NH2与聚氯乙烯（PVC）分子链上的C-Cl键反应活性位点发生亲核取代反应，通过非溶剂致相分离法（NIPS）制备了亲水性聚氯乙烯中空纤维膜，考察了葡甲胺浓度对膜亲水性的影响。研究发现，随着葡甲胺浓度增加，膜的亲水性和水通量提高。在此基础上，增加亲水性两亲性聚合物Pluronic F127作为致孔剂，采用NIPS法制备大孔径聚氯乙烯中空纤维膜。考察了Pluronc F127添加量对PVC膜孔径的影响。结果表明，当Pluronic F127的添加量增加，PVC膜的最大孔径先增大后减小，最高可达0.46 μm，此时水通量6430 L/m2?h?MPa，BSA透过率为95%，细胞截留率为100%，通量恢复率测试结果表明，与原膜相比，亲水性大孔径聚氯乙烯中空纤维膜的抗污染性能有效提升。

Hydrophilic polyvinyl chloride (PVC) hollow fiber membranes were prepared by non-solvent-initiated phase separation (NIPS) using polyvinyl chloride (PVC) as the membrane material and the polyhydroxy-amino compound meglumine was added to the casting solution, and the amino-NH2 group of putrescine undergoes nucleophilic substitution reaction with the reactive site of C-Cl bond on the polyvinyl chloride (PVC) molecular chain. Investigations conducted into the relationship between meglumine concentrations and PVC membrane hydrophilicity demonstrated that the hydrophilicity and water flux of the PVC membranes rose with increasing meglumine concentrations. On this basis, the hydrophilic amphiphilic polymer Pluronic F127 was added as a pore-forming agent, and large pore size PVC hollow fiber membranes were prepared by the NIPS method. The effect of the addition of Pluronic F127 on the pore size of PVC membranes showed that when the addition of Pluronic F127 increased, the maximum pore size of PVC membrane began to increase and then decreased up to 0.46 μm, at which time the water flux was 6430 L/m2?h?MPa, the BSA permeability and the cell rejection was 95% and 100% respectively, and the flux recovery of hydrophilic large pore size poly(vinyl chloride) hollow fiber membranes was increased compared to the original membranes.

基金项目：

天津市高等学校新型膜材料及膜分离技术创新团队(No. TD13-5044)

作者简介：

龙婷婷(1995-)，女，贵州黔东南人，硕士研究生，研究方向为蛋白质分离膜制备与应用

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