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超临界CO2制备壳聚糖/ 聚乙烯醇非对称膜及其性能研究

作者：翟晴晴¹，童欢²，曾静²，孙其勋¹，陈嘉琪¹，吴仲岿¹

单位： 1. 武汉理工大学材料科学与工程学院，武汉 430070; 2. 武汉市第三医院，武汉 430070

关键词：非对称膜；聚乙烯醇；壳聚糖；超临界CO2

DOI号： 10.16159/j.cnki.issn1007-8924.2024.06.013

分类号： TQ028

出版年,卷(期):页码： 2024,44(6):107-114

摘要：

非对称多孔膜类伤口敷料在治疗皮肤损伤方面有着非常重要的作用.目前,大多数非对称膜是通过干/湿相转化法制备而成,但该方法使用的溶剂和非溶剂大多具有细胞毒性,后续的干燥过程可能导致多孔结构坍塌.针对以上问题，此次研究以聚乙烯醇和壳聚糖为原料，通过超临界CO2相转化技术制备了一种非对称膜，并探究了不同质量分数铸膜液对膜的形貌结构和性能的影响规律.结果表明：所制备膜都具有明显的非对称结构，且非对称膜的力学性能（拉伸强度6.07~14.3 MPa,拉伸模量3.17~9.82 MPa）和吸水率（177.8%~254.0%）均在理想伤口敷料的期望范围内.随着铸膜液质量分数的增大，表层的致密程度和致密层厚度会相应增加，吸水率随之减小，拉伸强度随之增加.此外，8%铸膜液所制得的非对称膜同时拥有微孔、介孔和大孔，在伤口敷料领域有潜在的应用前景.

Wound dressings with asymmetric porous membranes play an important role in the treatment of skin injuries. At present, most asymmetric membranes are prepared by dry/wet phase transformation, but most solvents and non-solvents used in this method are cytotoxic, and the prolonged drying process can lead to the collapse of the porous structure. In view of the above problems, an asymmetric membrane was prepared by supercritical CO2 phase conversion using polyvinyl alcohol and chitosan as raw materials. The effects of different mass fractions of casting liquid (6%, 7%, 8%, 9%) on the morphology, structure and properties of the membrane were investigated. The results showed that all four membranes have obvious asymmetric structure, and the mechanical properties of the asymmetric films (tensile strength 6.07~14.3 MPa, tensile modulus 3.17~9.82 MPa) and water absorption (177.8%~254.0%) were within the desired range of ideal wound dressings. With the increase of the mass fraction of casting liquid, the density of the surface layer and the thickness of the dense layer increased correspondingly, the water absorption rate decreased, and the tensile strength increased. In addition, the asymmetric membrane produced by 8% casting liquid had micropores, mesoporous and macropores at the same time, which had a potential application prospect in the field of wound dressing.

基金项目：

湖北省自然科学基金项目（2022CFB888）

作者简介：

翟晴晴（1999-），女，河南焦作人，硕士研究生，研究方向为功能高分子多孔膜

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