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聚4-甲基-1-戊烯中空纤维氧合膜表面修饰研究

作者：童童¹，赵文静²，刘春玲³，于壮壮¹，查尚文²，张慎祥¹

单位： 1. 苏州大学材料与化学化工学部，苏州 215123； 2. 上海翊科聚合物科技有限公司，上海 201306； 3. 江苏苏净集团有限公司，苏州 215123

关键词： PMP中空纤维氧合膜；磷酰胆碱聚合物；表面改性；血液相容性

DOI号： 10.16159/j.cnki.issn1007-8924.2026.01.003

分类号： TQ316.6

出版年,卷(期):页码： 2026,46(1):27-36

摘要：

聚4-甲基-1-戊烯（PMP）中空纤维膜作为第三代氧合膜，具有优异抗血浆渗漏性与良好气体渗透性的优点，然而，较差的血液相容性已成为制约其长期使用的关键问题。为提高PMP膜材料血液相容性，本研究提出了一种磷酰胆碱聚合物（PMLT）修饰方法。为提高PMLT接枝稳定性，首先利用没食子酸（GA）的氧化自聚沉积在PMP膜表面引入羟基基团，然后将PMLT聚合物通过化学键接枝在PMP膜表面，形成稳定、连续的抗血栓涂层。场发射扫描电子显微镜（SEM）、傅里叶变换红外光谱（FTIR）、X射线光电子能谱（XPS）等表征结果验证了GA@PMLT复合涂层的成功制备，且涂层在生理盐水中振荡一周仍能稳定存在。在气体通量无明显下降的前提下，GA@PMLT涂层明显改善了PMP膜的血液相容性。本研究为氧合膜血液相容性修饰提供了新的思路。

Poly-4-methyl-1-pentene (PMP) hollow fiber membrane, as the third generation oxygenation membrane, has the advantages of preventing plasma leakage and high gas permeability. However, the poor blood compatibility has become a key issue that restricts long-term use in ECMO. In order to improve its blood compatibility, phosphorylcholine polymer, poly(MPC-co-LMA-co-TSMA) (PMLT) were synthesized. In order to enhance the stability of grafting, the hydroxyl groups were introduced on the surface of PMP membrane by oxidative self-polymerization of gallic acid, and the PMLT was grafted through the chemical bond to form a stable and continuous antithrombotic coating. The results of SEM, FTIR, XPS and water contact angles verified that the GA@PMLT coating was successfully prepared, and the coating could exist stably in normal saline for one week. The GA@PMLT coating did not significantly affect the gas permeability of the membrane, and improved the blood compatibility of the PMP membrane. This study provides a new idea for the blood compatibility modification of oxygenation membrane.

基金项目：

姑苏创新创业领军人才计划项目（ZXL2023198）；工业和信息化部生物医用材料创新任务揭榜挂帅项目；江苏省科技厅省重点研发计划，增材制造高性能分离膜关键技术研发（BE2022056)

作者简介：

童童（2001-），男，江西上饶人，硕士研究生，主要研究方向为功能高分子材料

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