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基于CFD的浓差极化汲取膜浓缩过程强化研究

作者：殷嘉伟¹，²，杨旭²，沈飞²，林春香¹，万印华²，陈国强²

单位： 1. 福州大学先进制造学院，晋江 362251； 2. 中国科学院过程工程研究所生物药制备与递送全国重点实验室，北京 100190

关键词：浓差极化汲取； CFD模拟；重力场电场的复合场；蛋白黏度；入口流速

DOI号： 10.16159/j.cnki.issn1007-8924.2026.01.015

分类号： TQ028

出版年,卷(期):页码： 2026,46(1):154-163

摘要：

浓差极化汲取膜浓缩技术能够提取高倍蛋白浓缩液的浓差极化层，具有低剪切、低能耗的优势，但目前仍缺乏浓差极化层的高效汲取方法。为提高该技术对蛋白的浓缩效率，本研究采用计算流体力学（CFD），构建了二维数值模型，系统模拟了外场（重力场、电场及重力场电场的复合场）和重要过程参数（蛋白黏度及入口流速）对浓差极化层迁移行为和汲取效率的影响。结果表明，重力场、电场及复合场都能有效促进浓差极化层的迁移。其中，复合场对浓差极化的汲取效率最高。此外，蛋白黏度和入口流速的提高均会对汲取效率产生负面影响。该研究以CFD模拟揭示了施加外场和过程参数对浓差极化汲取技术的重要作用，为该技术的过程强化和控制策略开发提供指导。

The concentration polarization (CP) extraction-based membrane concentration technology enables the collection of high-concentration protein solutions from the CP layer, offering advantages such as low shear stress and low energy consumption. However, efficient methods for extracting the CP layer are still lacking. To improve the protein concentration efficiency of this technique, this study employed computational fluid dynamics (CFD) to construct a two-dimensional numerical model that systematically simulated the effects of external fields (gravitational field, electric field, and combined gravitational and electric fields) and key process parameters (protein viscosity and inlet flow velocity) on the performance of migration and extraction of the CP layer. The results showed that all the external fields could effectively enhance the CP layer’s migration, with the combined fields achieving the highest extraction efficiency. Additionally, increased protein viscosity and inlet flow velocity negatively affected the extraction performance. This study used CFD simulation to elucidate the critical role of external fields and process parameters in the CP layer extraction based membrane concentration technique, providing valuable guidance for developing such emerging technology’s process intensification and control strategy.

基金项目：

国家自然科学基金面上项目（22178352）；中国科学院百人计划项目（2023000366）

作者简介：

殷嘉伟（1998-），男，江苏宜兴人，硕士研究生，研究方向为生物大分子的膜分离

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